England, who won the first ODI by seven wickets at Grace Road on Tuesday, will attempt to complete a series whitewash in the final match at Taunton on Monday.
England women made their highest one-day total and secured the series against Pakistan with an emphatic 212-run win at New Road.
They hit 39 fours and 11 sixes in 378-5, with 132 made in the final 10 overs.
Openers Lauren Winfield and Tammy Beaumont scored maiden ODI centuries in a stand of 235 and Natalie Sciver struck six sixes in a 33-ball 80.
Anya Shrubsole took 4-19 as Pakistan were bowled out for 166 in the 48th over, despite Bismah Maroof’s 61.
A three-match Twenty20 series starts at Bristol on 3 July.
England 378-5 (50 overs): Winfield 123, Beaumont 104, Sciver 80