Writing in the New York Times, Ms Hayek, 51, described working with the film mogul on what she called her “greatest ambition” – telling the story of Mexican artist Frida Kahlo.
She wrote that, after striking a deal with Mr Weinstein for the rights of the film that would eventually become 2002’s Frida, she was forced to repeatedly refuse sexual advances.
“No to me taking a shower with him.
“No to letting him watch me take a shower.
“No to letting him give me a massage.
“No to letting a naked friend of his give me a massage.
“No to letting him give me oral sex.
“No to my getting naked with another woman,” she wrote.
She went on to accuse him of threatening to shut the film down unless she filmed a nude sex scene with another actress.
“I had to take a tranquilizer, which eventually stopped the crying but made the vomiting worse,” she wrote of her emotional turmoil at filming a scene she thought unnecessary.
“As you can imagine, this was not sexy, but it was the only way I could get through the scene.”
Ms Baird, Mr Weinstein’s spokeswoman, said: “Mr Weinstein does not recall pressuring Salma to do a gratuitous sex scene with a female costar and he was not there for the filming,” a statement said.
“All of the sexual allegations as portrayed by Salma are not accurate and others who witnessed the events have a different account of what transpired.”
Frida would eventually gather six Oscar nominations, including a Best Actress nod for Ms Hayek.
Mr Weinstein has been accused of rape, sexual assault and harassment, but has “unequivocally denied” any allegations of non-consensual relationships.
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